This is an interesting building. It is labeled as The Bedford Falls Boarding House, but it wasn't actually a boarding house until the Pottersville sequence. In the real world, it was always Ma and Pa Bailey's home.
The side of the box is hard to read, but says in part, "If you need a nice clean room, the best place to to is the boarding house run by Mrs. Bailey, George's mother. (unintelligible)."